Roxalana "Roxana" Druse (née Teftt; born c. 1847 – hanged February 28, 1887), was the last woman hanged in the state of New York. The first woman to be hanged in four decades in Central New York, her botched execution resulted in the decision to replace the gallows with the electric chair in 1890.

Mrs. Druse murdered her husband, William Druse, in their home in Warren, New York. The murder unfolded with the help of her son and daughter, George and Mary Druse, and nephew Frank Gates. The family members were threatened with death if they refused and all had an involvement with the murder case. Druse claimed that her motive was that her husband was abusive to her and was not supporting the family because he had left for a number of days after an argument. Frank Gates and George Druse were later released due to their lack of involvement in the murder. During the trial, Mary Druse admitted to assisting in the murder, and was sentenced to life at the Onondaga Country penitentiary. On October 6, 1885 Roxalana was sentenced to be hanged.